GRAND RAPIDS, Mich. (Aug. 5, 2021) — Stephanie Grainger, Ph.D., hopes to uncover the secrets of stem cells and their role in cancer, and she’s investigating specific type of cellular communication to do it.
At VAI, Grainger and her team will investigate how stem cells are made, how they are maintained and — when things go wrong — how they can become cancerous. Understanding these complex processes holds great promise for better understanding health and developing new treatments for cancer and other diseases.
“Traditional cancer therapies do not target the rare cells that initiate cancer growth, and instead take a brute force approach of killing any cells that are growing. This includes the cells in your intestine, skin and hair, and is why chemotherapy causes side effects like an upset stomach and hair loss. These rare cells, which behave similarly to a specialized group of cells in our bodies called stem cells, are often able to regrow tumors once therapy is withdrawn,” Grainger said. “One of the main goals of my research group at VAI is to figure out how these rare cells talk to each other in normal and cancerous conditions. Once we figure that out, we can more effectively kill off these cells that initiate cancer.”
If the human body is an ongoing construction project, then stem cells are its all-purpose building materials. These biological “blank slates” give rise to all the specialized cell types needed to assemble and power the human body, from skin cells to heart cells and everything in between. They also help maintain the body throughout life by replacing dead cells and rejuvenating damaged tissues.
Grainger is particularly interested in a cellular communication channel called Wnt (pronounced “Wint”) that is central to a host of normal processes, such as embryonic development and tissue regeneration. The Wnt pathway also is a well-known player in cancer and bone diseases, as well as other disorders.
“Dr. Grainger is at the cutting-edge of stem cell biology. Her research already has illuminated critical new facets of the Wnt pathway that had not previously been described,” said VAI Professor Bart Williams, Ph.D., a member of the recruitment committee and internationally recognized Wnt expert. “She is an outstanding scientist and a fantastic addition to our team. We are excited she chose VAI as her new scientific home.”
Grainger is the second faculty member to join VAI in 2021. Her recruitment is part of an ongoing strategic initiative to expand and bolster VAI’s research programs.
ABOUT VAN ANDEL INSTITUTE
Van Andel Institute (VAI) is committed to improving the health and enhancing the lives of current and future generations through cutting edge biomedical research and innovative educational offerings. Established in Grand Rapids, Michigan, in 1996 by the Van Andel family, VAI is now home to more than 400 scientists, educators and support staff, who work with a growing number of national and international collaborators to foster discovery. The Institute’s scientists study the origins of cancer, Parkinson’s and other diseases and translate their findings into breakthrough prevention and treatment strategies. Our educators develop inquiry-based approaches for K-12 education to help students and teachers prepare the next generation of problem-solvers, while our Graduate School offers a rigorous, research-intensive Ph.D. program in molecular and cellular biology. Learn more at vai.org.
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